The retrotransposon Long Interspersed Element 1 (LINE‐1 or L1) has played a major role in shaping the sequence composition of the mammalian genome. In our recent publication, “Heritable L1 retrotransposition in the mouse primordial germline and early embryo,” we systematically assessed the rate and developmental timing of de novo, heritable endogenous L1 insertions in mice. Such heritable retrotransposition events allow L1 to exert an ongoing influence upon genome evolution. Here, we place our findings in the context of earlier studies, and (...) highlight how our results corroborate, and depart from, previous research based on human patient samples and transgenic mouse models harboring engineered L1 reporter genes. In parallel, we outline outstanding questions regarding the stage‐specificity, regulation, and functional impact of embryonic and germline L1 retrotransposition, and propose avenues for future research in this field. -/- . (shrink)

Spelke's sweeping proposal requires greater precision in specifying the place of language in early cognition. We now know by 3 months of age, infants have already begun to forge a link between language and core cognition. This precocious link, which unfolds dynamically over development, may indeed offer an entry point for acquiring higher-order, abstract conceptual and representational capacities.

Dominant discourses of recovery permeate substance use research, policy, and practice recommendations around the world, exercising the power to shape the identities of people with substance use issues. Drawing on Foucauldian and intersectionality theories, this study explores power operations embedded in recovery discourses constructing a certain type of recovery for a certain type of subject. A critical discourse analysis using van Leeuwen’s social semiotic approach examines two Canadian federal recovery documents to consider the discursive representation of people with substance use (...) issues, legitimization of recovery, and interpretation of space. Findings suggest that substance use recovery discourses are entwined in a complex web of neoliberal, biomedical, and moral discourses by which stigmatized identities are (co)constructed at micro, mezzo, and macro levels. This study offers a unique and relevant opportunity to complicate the dominant recovery literature by challenging oppression, deconstructing normative identities, and facilitating the empowerment of marginalized populations. (shrink)

Gene retrocopies are generated by reverse transcription and genomic integration of mRNA. As such, retrocopies present an important exception to the central dogma of molecular biology, and have substantially impacted the functional landscape of the metazoan genome. While an estimated 8,000–17,000 retrocopies exist in the human genome reference sequence, the extent of variation between individuals in terms of retrocopy content has remained largely unexplored. Three recent studies by Abyzov et al., Ewing et al. and Schrider et al. have exploited 1,000 (...) Genomes Project Consortium data, as well as other sources of whole‐genome sequencing data, to uncover novel gene retrocopies. Here, we compare the methods and results of these three studies, highlight the impact of retrocopies in human diversity and genome evolution, and speculate on the potential for somatic gene retrocopies to impact cancer etiology and genetic diversity among individual neurons in the mammalian brain. (shrink)

Bloom provides a masterful synthesis of recent advances in word-learning, placing them within the framework of abiding theoretical issues. I will augment and challenge his approach by underscoring the significance of word extension for questions concerning (a) the origin and evolution of infants' expectations, and (b) domain-specificity in word-learning.

Questions about concepts bring into play all the cognitive science disciplines. For many centuries, concepts belonged to philosophy; but more recently, these original caretakers have shared responsibility for this domain with cognitive and developmental psychology, linguistics, artificial intelligence, anthropology, and neuroscience. Each of these fields has offered insights into these building blocks of thought, and each has contributed a unique perspective on fundamental questions about the nature of minds. However, the integrative approach of cognitive science holds the promise of providing (...) new vantage points from a range of disciplines on this core issue. (shrink)

Rhythm is key to language acquisition. Across languages, rhythmic features highlight fundamental linguistic elements of the sound stream and structural relations among them. A sensitivity to rhythmic features, which begins in utero, is evident at birth. What is less clear is whether rhythm supports infants' earliest links between language and cognition. Prior evidence has documented that for infants as young as 3 and 4 months, listening to their native language supports the core cognitive capacity of object categorization. This precocious link (...) is initially part of a broader template: listening to a non-native language from the same rhythmic class as and to vocalizations of non-human primates provide English-acquiring infants the same cognitive advantage as does listening to their native language. Here, we implement a machine-learning approach to ask whether there are acoustic properties, available on the surface of these vocalizations, that permit infants' to identify which vocalizations are candidate links to cognition. We provided the model with a robust sample of vocalizations that, from the vantage point of English-acquiring 4-month-olds, either support object categorization or fail to do so. We assess whether supervised ML classification models can distinguish those vocalizations that support cognition from those that do not, and which class of acoustic features best support that classification. Our analysis reveals that principal components derived from rhythm-relevant acoustic features were among the most robust in supporting the classification. Classifications performed using temporal envelope components were also robust. These new findings provide in principle evidence that infants' earliest links between vocalizations and cognition may be subserved by their perceptual sensitivity to rhythmic and spectral elements available on the surface of these vocalizations, and that these may guide infants' identification of candidate links to cognition. (shrink)

Infants’ initially broad links between language and object categories are increasingly tuned, becoming more precise by the end of their first year. In a longitudinal study, we asked whether individual differences in the precision of infants’ links at 12 months of age are related to vocabulary development. We found that, at 12 months, infants who had already established a precise link between labels and categories understood more words than those whose link was still broad. Six months later, this advantage held: (...) At 18 months, infants who had demonstrated a precise link at 12 months knew and produced more words than did infants who had demonstrated a broad link at 12 months. We conclude that individual differences in the precision of 12-month-old infants’ links between language and categories provide a reliable window into their vocabulary development. We consider several causal explanations of this relation. (shrink)

This collection provides a thorough grounding in the philosophy of American pragmatism by examining the views of four principal thinkers - Charles S. Peirce, William James, John Dewey, and George Herbert Mead - on issues of central and enduring importance to life in human society. Pragmatism emerged as a characteristically American response to an inheritance of British empiricism. Presenting a radical reconception of the nature of experience, pragmatism represents a belief that ideas are not merely to be contemplated but must (...) be put into action, tested and refined through experience. At the same time, the American pragmatists argued for an emphasis on human community that would offset the deep-seated American bias in favor of individualism. Far from being a relic of the past, pragmatism offers a dynamic and substantive approach to questions of human conduct, social values, scientific inquiry, religious belief, and aesthetic experience that lie at the center of contemporary life. This volume is an invaluable introduction to a school of thought that remains vital, instructive, and provocative. (shrink)

Gordon's emphasizes that the process of prosecution is crucial to the idea of crime. One who commits a public wrong is properly called to public account for it, and the criminal trial constitutes such a public calling to account. The state is the proper prosecutor of crimes: since a crime is ‘our’ wrong, rather than only the victim's wrong, it is appropriate that we should prosecute it, collectively. The case is not simply V the victim, or P the plaintiff, against (...) D the defendant. It is brought, as the Americans properly have it, by ‘the People’, or by ‘the Commonwealth’, against the defendant. This is a useful way in which to think about crimes and criminalisation. This chapter tries to develop this conception of public wrongs a little further, which also involves complicating it more than a little. It works from a version of liberal communitarianism that rejects the metaphysical version of the individualist's ‘unencumbered self’; but the account sketched here should be compatible with all but the most radically individualist kinds of liberal theory. (shrink)

Recent research suggests that selectively attending to relevant stimuli while having to ignore or resist conflicting stimuli can lead to improvements in learning. While mostly discussed within a broader “desirable difficulty” framework in the memory and education literatures, some recent work has focused on more mechanistic questions of how processing conflict (e.g., from incongruent primes) might elicit increased attention and control, producing enhanced incidental encoding of high-conflict stimuli. This encoding benefit for high-control-demand or high-difficulty situations has been broadly conceptualized as (...) a task-general property, with no strong prediction of what particular task elements should produce this effect. From stage processing models of single- and dual-task performance, we propose that memory-enhancing difficulty manipulations should strongly depend on inducing additional cognitive control at particular processing stages. Over six experiments, we show that a memory benefit is produced when increased cognitive control ( via incongruency priming) focuses additional processing on the core meaning of to-be-tested stimuli at the semantic categorization stage. In contrast, incongruency priming targeted at response selection within the same task produces similar effects on initial task performance, but gives no memory benefit for high-conflict trials. We suggest that a simple model of limited-capacity and stage-specific cognitive control allocation can account for and predict where and when conflict/difficulty encoding benefits will occur, and may serve as a model for desirable difficulty effects more broadly. (shrink)

The logic BN4 can be considered as the 4-valued logic of the relevant conditional and the logic E4, as the 4-valued logic of entailment. The aim of this paper is to endow E4 with a 2-set-up Routley-Meyer semantics. It is proved that E4 is strongly sound and complete w.r.t. this semantics.